Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

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Author(s)

    • Kairupan Tara Sefanya
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Faculty of Medicine, Sam Ratulangi University
    • Nerome Yasuhito
    • Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
    • Owaki Tetsuhiro
    • Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
    • Takezaki Toshiro
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
    • Ibusuki Rie
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
    • Nindita Yora
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Faculty of Medicine, Diponegoro University
    • Kuwabara Kazuyo
    • Department of Preventive Medicine and Public Health, Keio University School of Medicine

Abstract

<p><i>Background:</i> An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.</p><p><i>Method:</i> We selected 2180 sub-cohort subjects aged 35–69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from <i>TNF-</i>α, <i>IL-10,</i> and <i>NF-</i>κ<i>B1</i>. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.</p><p><i>Results:</i> HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between <i>TNF</i>-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (<i>p</i> = 0.020). No significant interaction was observed between <i>IL-10</i> 819T/C or <i>NF-</i>κ<i>B1</i> 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18–7.77).</p><p><i>Conclusion:</i> The present study found the interaction between <i>TNF</i>-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.</p>

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 27(9), 420-427, 2017

    Japan Epidemiological Association

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