Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis
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- Mori Junpei
- Graduate School of Biomedical and Health Science, Hiroshima University
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- Sanoh Seigo
- Graduate School of Biomedical and Health Science, Hiroshima University
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- Kashiwagi Keiko
- Amphibian Research Center, Hiroshima University
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- Hanada Hideki
- Amphibian Research Center, Hiroshima University
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- Shigeta Mitsuki
- Graduate School of Science, Hiroshima University
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- Suzuki Ken-ichi T.
- Graduate School of Science, Hiroshima University
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- Yamamoto Takashi
- Graduate School of Science, Hiroshima University
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- Kotake Yaichiro
- Graduate School of Biomedical and Health Science, Hiroshima University
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- Sugihara Kazumi
- Faculty of Pharmaceutical Sciences, Hiroshima International University
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- Kitamura Shigeyuki
- Nihon Pharmaceutical University
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- Kashiwagi Akihiko
- Amphibian Research Center, Hiroshima University
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- Ohta Shigeru
- Graduate School of Biomedical and Health Science, Hiroshima University
書誌事項
- タイトル別名
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- Developmental changes in drug-metabolizing enzyme expression during metamorphosis of <i>Xenopus tropicalis </i>
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抄録
<p>A large number of chemicals are routinely detected in aquatic environments, and these chemicals may adversely affect aquatic organisms. Accurate risk assessment requires understanding drug-metabolizing systems in aquatic organisms because metabolism of these chemicals is a critical determinant of chemical bioaccumulation and related toxicity. In this study, we evaluated mRNA expression levels of nuclear receptors and drug-metabolizing enzymes as well as cytochrome P450 (CYP) activities in pro-metamorphic tadpoles, froglets, and adult frogs to determine how drug-metabolizing systems are altered at different life stages. We found that drug-metabolizing systems in tadpoles were entirely immature, and therefore, tadpoles appeared to be more susceptible to chemicals compared with metamorphosed frogs. On the other hand, cyp1a mRNA expression and CYP1A-like activity were higher in tadpoles. We found that thyroid hormone (TH), which increases during metamorphosis, induced CYP1A-like activity. Because endogenous TH concentration is significantly increased during metamorphosis, endogenous TH would induce CYP1A-like activity in tadpoles.</p>
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 42 (5), 605-613, 2017
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679883163648
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- NII論文ID
- 130006076698
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- NII書誌ID
- AN00002808
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 028610253
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- PubMed
- 28904296
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可