Effectiveness of Plasmapheresis in a Patient with Anti-glomerular Basement Membrane Antibody Glomerulonephritis with Advanced Kidney Dysfunction

この論文にアクセスする

この論文をさがす

著者

    • Usui Toshiaki
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Kai Hirayasu
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Noguchi Kazuyuki
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Morito Naoki
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Usui Joichi
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Saito Chie
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan
    • Uesugi Noriko
    • Department of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Japan
    • Nagata Michio
    • Department of Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, Japan
    • Yamagata Kunihiro
    • Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan

抄録

Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis.

<p>Patients with anti-glomerular basement membrane antibody glomerulonephritis (anti-GBM GN) have severe kidney dysfunction, leading to end-stage renal disease. The effect of plasmapheresis and immunosuppressive treatment in patients with severe glomerular changes is controversial. A 62-year-old man was admitted with rapidly progressive glomerulonephritis and diagnosed with anti-GBM GN. He required hemodialysis. All glomeruli in the kidney biopsy specimen had cellular crescents without fibrotic changes, suggesting reversible damage. He was treated with plasmapheresis until the anti-glomerular basement membrane antibodies disappeared. His kidney function recovered, and dialysis was able to be discontinued. Frequent plasmapheresis in patients with dialysis-dependent anti-GBM GN may improve the kidney prognosis. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 56(18), 2475-2479, 2017

    一般社団法人 日本内科学会

各種コード

ページトップへ