免疫系と精神疾患─ BDNF,proBDNF と細胞内 Ca²⁺シグナリングの関与─  [in Japanese] Immune system and psychiatric disorders: involvement of BDNF, proBDNF and intracellular Ca²⁺ signaling  [in Japanese]

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Author(s)

Abstract

がん,糖尿病などの身体疾患,肥満など生活習慣病およびうつ病を含む精神疾患にはいずれも慢性炎症が病態に関与するとされる。心身相互に影響する共通の分子機序として,免疫系の関与が重要であるが,精神疾患の病態においては脳内ミクログリア活性化が重要な位置を占める。ミクログリアの生理的機能を解明しつつ,向精神薬の作用を検討していくことは今後も重要であり,うつ病を含む各精神疾患の病態仮説にかかわる BDNF,proBDNF および細胞内 Ca²⁺ シグナリングに着目したい。

Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cancer, type 2 diabete, cardiovascular diseases, obesity and psychiatric disorders such as depression. There is increasing evidence suggesting that pathophysiology of psychiatric disorders is related to the inflammatory responses mediated by microglial cells. Elevation of intracellular Ca²⁺ is important in activation of microglial cell functions, including proliferation, release of NO, cytokines and BDNF. It has been shown that alteration of intracellular Ca²⁺ signaling underlies the pathophysiology of psychiatric disorders, including schizophrenia, depression and bipolar disorders. Microglial cells are able to respond to BDNF, which may be important for the regulation of inflammator y responses, and may also be involved in the pathophysiology and/or the treatment of psychiatric disorders. In addition, we also need to examine the effect of proBDNF on microglial function.

Journal

  • Japanese Journal of Biological Psychiatry

    Japanese Journal of Biological Psychiatry 27(1), 15-21, 2016

    Japanese Society of Biological Psychiatry

Codes

  • NII Article ID (NAID)
    130006100301
  • NII NACSIS-CAT ID (NCID)
    AA12468060
  • Text Lang
    JPN
  • ISSN
    2186-6619
  • NDL Article ID
    027289509
  • NDL Call No.
    Z19-3169
  • Data Source
    NDL  J-STAGE 
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