Propensity Score Analysis in the Comparison of Long-Term Outcomes for Locally Advanced Colon Cancer Between Laparoscopic Colectomy and Open Colectomy

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Author(s)

Abstract

<p><b><i>Objective: </i></b>It is difficult to conduct a randomised control trial in a single institution because of the small number of cases. The current study was conducted to investigate if there is any difference in long-term outcome between laparoscopic surgery (LAC) and open surgery (OC) using propensity-score matching analysis based on prognostic factors.</p><p><b><i>Materials: </i></b>Two hundred and sixteen patients with locally-advanced colon cancer who underwent surgery with curative intent at our department between 2002 and 2010 were enrolled in the current study.</p><p><b><i>Methods: </i></b>Propensity score matching analysis and Inverse Probability Weighting (IPW) estimator were used to adjust for differences in the clinicopathological severity between LAC and OC.</p><p><b><i>Results: </i></b>Before propensity score matching analysis recurrence-free survival in LAC was statistically better than that in OC (Hazard ratio= 0.59, 95% CI 0.35-0.98, p=0.04), and no statistically significant difference was recognized for cancer-specific survival (Hazard ratio=0.63, 95% CI 0.27-1.37, p=0.25). After propensity score matching analysis there were no statistically significant differences for recurrence-free (Hazard ratio=0.91, 95% CI 0.41-2.01, p=0.81) or cancer-specific survival (Hazard ratio=1.38, 95% CI 0.41-4.82, p=0.59). In addition, the IPW estimator revealed that the difference for recurrence-free survival was not significant between the two groups.</p><p><b><i>Conclusion: </i></b>The one-to-one pair propensity score matching successfully balanced the clinicopathological factors between LAC and OC. The propensity score matching analysis demonstrated no significant difference between LAC and OC.</p>

Journal

  • Juntendo Medical Journal

    Juntendo Medical Journal 63(4), 264-272, 2017

    The Juntendo Medical Society

Codes

  • NII Article ID (NAID)
    130006106309
  • NII NACSIS-CAT ID (NCID)
    AA1262207X
  • Text Lang
    ENG
  • Journal Type
    大学紀要
  • ISSN
    2187-9737
  • NDL Article ID
    028604892
  • NDL Call No.
    Z19-432
  • Data Source
    NDL  J-STAGE 
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