Effective waist circumference reduction rate necessary to avoid the development of type 2 diabetes in Japanese men with abdominal obesity
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- Kashiwagi Risa
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Iwahashi Hiromi
- Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
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- Yamada Yuya
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Sakaue Takaaki
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Okita Tomonori
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Kawachi Yusuke
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Iwamoto Ryuya
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Saisho Kenji
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Tamba Sachiko
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Yamamoto Koji
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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- Watanabe Takehiko
- Physical Check up Center, Sumitomo Hospital, Osaka, Japan
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- Fujimoto Takashi
- Physical Check up Center, Sumitomo Hospital, Osaka, Japan
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- Matsuzawa Yuji
- Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan
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Abstract
The aim of this study was to determine the effective waist circumference (WC) reduction rate in avoiding the development of type 2 diabetes mellitus (T2DM) in <55 years and ≥55 years Japanese men with abdominal obesity. The study subjects were 795 men with WC ≥85 cm, fasting plasma glucose <126 mg/dL, 2-hr plasma glucose on 75 g of oral glucose tolerance test <200 mg/dL, and HbA1c 5.6-6.4 % (38-40 mmol/mol) at baseline who underwent general health checkups more than twice between April 2007 and May 2015. They were divided into 5 groups based on the change in WC during the observation period (WC gain group, and four groups stratified according the rate of WC loss). The subjects were also divided into the <55 years and ≥55 years (at baseline) subgroups. The cumulative incidence rate of T2DM was analyzed and compared among the groups. The cumulative incidence rates of the largest WC loss quartile (≥5.45 %) in all age, of the largest WC loss quartile (≥5.60 %) and second largest WC loss quartile (3.44-5.59 %) in the <55 years subgroup, and of the largest WC loss quartile (≥5.37 %) in the ≥55 years subgroup were significantly lower than that of the gain group (p<0.001, p=0.009, 0.012, and 0.012, respectively). WC reduction rate of at least about 3 % in the younger (<55 years) and at least about 5 % in the older (≥55 years) non-diabetic Japanese men with abdominal obesity can effectively reduce the chance of development of T2DM.
Journal
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- Endocrine Journal
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Endocrine Journal 64 (9), 881-894, 2017
The Japan Endocrine Society
