Osr2 (odd-skipped related 2) はマウス歯乳頭細胞の硬組織形成細胞への分化を促進する

DOI
  • 川島 伸之
    東京医科歯科大学 (TMDU) 大学院医歯学総合研究科口腔機能再構築学講座歯髄生物学分野
  • 齋藤 正寛
    東北大学大学院歯学研究科口腔修復学講座歯科保存学分野
  • 興地 隆史
    東京医科歯科大学 (TMDU) 大学院医歯学総合研究科口腔機能再構築学講座歯髄生物学分野

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  • Osr2 (odd-skipped related 2) induced differentiation of hard-tissue forming cells in mouse dental papilla cells

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<p>Abstract : The odd-skipped related (Osr) gene is a zinc-finger transcription factor that is involved in embryonic development and bone formation. The aim of this study was to evaluate the role of Osr2 in odonto/osteoblastic differentiation of mouse dental papilla cells (MDPs). Osr2 mRNA expression in the dental pulp tissues of upper and lower incisors and gingival tissues was examined using C57BL/6 mice. MDPs were cultured in α-modified minimum essential medium containing 10% fetal bovine serum and antibiotics. The Osr2 expression vector was transfected into MDPs, and a stable cell line was selected. Relatively high expression of Osr2 was detected in the dental pulp tissues compared to gingival tissues. Enhanced expression of Osr2 in MDPs promoted the expression of odonto/osteoblastic genes and nodule formation. These results suggested the involvement of Osr2 in the odonto/osteoblastic differentiation of MDPs/dental pulp cells, which may occur in the mature dental pulp tissues.</p>

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