Metabolic regulation specific to leukemia stem cells

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  • NAKA Kazuhito
    Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University

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  • 代謝を標的とした白血病幹細胞制御
  • タイシャ オ ヒョウテキ ト シタ ハッケツビョウ カンサイボウ セイギョ

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Abstract

<p>Leukemia stem cells (LSCs) are responsible for relapse of leukemia. LSCs maintain their self-renewal capacity, stemness properties, and therapeutic resistance in a manner dependent on their cell of origin and genetic alterations acquired during subsequent clonal evolution. Specific mechanisms of metabolic control and nutrient acquisition are implicated in the regulation of LSC survival. Recent advances in gene modification strategies in mice and in sophisticated metabolomics technologies are producing novel inquiries in LSC research performed in vivo. In this review, I examined our current knowledge on the roles of various metabolic pathways, including glucose metabolism, lipid oxidation, and an alternative route of amino acid and peptide supply, that support the maintenance of self-renewal capacity and therapeutic resistance in LSCs in vivo.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (10), 1818-1827, 2017

    The Japanese Society of Hematology

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