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- 藤谷 雄二
- 国立研究開発法人 国立環境研究所
書誌事項
- タイトル別名
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- Scale Differences in Various Aerosol Exposure Methods and Their Estimation of Aerosol Deposition
- シュジュ ノ エアロゾル バクロ ジッケン シュホウ ニ ヨル スケール ノ チガイ ト チンチャクリョウ ノ スイテイ
この論文をさがす
抄録
<p> To investigate the pulmonary toxicity of various atmospheric aerosols or airborne engineered nanomaterials, cell-based in vitro studies that use air-liquid interface exposure systems and in vivo inhalation exposure studies that use laboratory animals by either nose-only exposure system or whole body exposure system are commonly employed. In this report, the feature of each exposure system is demonstrated. </p><p>Taking the scale of each exposure system into consideration, a target concentration of the airborne particles in the exposure system that is equivalent to the dose in human lungs in the environment was estimated using deposition efficiency, target surface area, and ventilation. If an adult man during light exercise inhales 100-nm spherical particles at the concentration of 15 μg/m3, which is an environmental standard value of PM2.5 in Japan, the particle deposition rate in the lung is calculated to be 0.037 μg/m2/h. The concentrations that lead to the same deposition rate for cells in the air-liquid interface exposure system and rats in the inhalation exposure system are 1 μg/m3 and 4.6 μg/m3, respectively. </p>
収録刊行物
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- エアロゾル研究
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エアロゾル研究 32 (3), 151-156, 2017
日本エアロゾル学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204343532032
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- NII論文ID
- 130006138843
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- NII書誌ID
- AN10041511
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- ISSN
- 1881543X
- 09122834
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- NDL書誌ID
- 028547330
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可