Blood pressure components and the risk for proteinuria in Japanese men: The Kansai Healthcare Study

• Shibata Mikiko

  Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine

• Sato Kyoko Kogawa

  Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine

• Uehara Shinichiro

  Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine

• Koh Hideo

  Hematology, Osaka City University Graduate School of Medicine

• Kinuhata Shigeki

  Medical Education and General Practice, Osaka City University Graduate School of Medicine

• Oue Keiko

  Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation

• Kambe Hiroshi

  Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation

• Morimoto Michio

  Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation

• Hayashi Tomoshige

  Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine

Abstract

Background: We examined prospectively which of the four blood pressure (BP) components (systolic BP [SBP], diastolic BP [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) was best in predicting the risk of proteinuria. Methods: This prospective study included 9341 non-diabetic Japanese middle-aged men who had no proteinuria and an estimated glomerular filtration rate ≥60 mL/min/1.73 m² and were not taking antihypertensive medications at entry. Persistent proteinuria was defined if proteinuria was detected two or more times consecutively and persistently at the annual examination until the end of follow-up. We calculated the difference in values of Akaike's information criterion (ΔAIC) in comparison of the BP components-added model to the model without them in a Cox proportional hazards model. Results: During the 84,587 person-years follow-up period, we confirmed 151 cases of persistent proteinuria. In multiple-adjusted models that included a single BP component, the hazard ratios for persistent proteinuria for the highest quartile of SBP, PP, and MAP were 3.11 (95% confidence interval [CI], 1.79–5.39), 1.87 (95% CI, 1.18–2.94), and 2.21 (95% CI, 1.33–3.69) compared with the lowest quartile of SBP, PP, and MAP, respectively. The hazard ratio for the highest quartile of DBP was 2.69 (95% CI, 1.65–4.38) compared with the second quartile of DBP. Of all models that included a single BP component, those that included SBP alone or DBP alone had the highest values of ΔAIC (14.0 and 13.1, respectively) in predicting the risk of persistent proteinuria. Conclusions: Of all BP components, SBP and DBP were best in predicting the risk of persistent proteinuria in middle-aged Japanese men.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 27 (11), 505-510, 2017

  Japan Epidemiological Association

Keywords

• Blood pressure components
• Proteinuria
• Chronic kidney disease
• Prospective cohort study
• Epidemiology

Details

• CRID: 1390001204476647552
• NII Article ID: 130006139939
• DOI: 10.1016/j.je.2016.10.010
• ISSN: 13499092
• ISSN: 09175040
• Web Site: http://api.elsevier.com/content/article/PII:S0917504017301211?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S0917504017301211?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2018287520
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed