Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome

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Author(s)

    • Yagi Shusuke
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences|Department of Community Medicine and Human Resource Development, Tokushima University Graduate School of Biomedical Sciences|Department of Internal Medicine, Shikoku Central Hospital
    • Yamaguchi Koji
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Kusunose Kenya
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Yamada Hirotsugu
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Wakatsuki Tetsuzo
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Shimabukuro Michio
    • Department of Cardio-Diabetes Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Akaike Masashi
    • Departments of Medical Education, Tokushima University Graduate School of Biomedical Sciences
    • Sata Masataka
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Soeki Takeshi
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Aihara Ken-ichi
    • Department of Community Medicine for Diabetes and Metabolic Disorders, Tokushima University Graduate School of Biomedical Sciences
    • Fukuda Daiju
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Ise Takayuki
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Kadota Muneyuki
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Bando Sachiko
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Matsuura Tomomi
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences
    • Tobiume Takeshi
    • Department of Cardiovascular Medicine, Tokushima University Graduate School of Biomedical Sciences

Abstract

<p>The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.</p>

Journal

  • International Heart Journal

    International Heart Journal 58(5), 720-723, 2017

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130006179141
  • Text Lang
    ENG
  • ISSN
    1349-2365
  • Data Source
    J-STAGE 
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