Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations

• Kanazawa Jun

  Department of Pulmonary Medicine, University of Tsukuba

• Masuko Hironori

  Department of Pulmonary Medicine, University of Tsukuba

• Yatagai Yohei

  Department of Pulmonary Medicine, University of Tsukuba

• Sakamoto Tohru

  Department of Pulmonary Medicine, University of Tsukuba

• Yamada Hideyasu

  Department of Pulmonary Medicine, University of Tsukuba

• Kaneko Yoshiko

  Department of Pulmonary Medicine, University of Tsukuba

• Kitazawa Haruna

  Department of Pulmonary Medicine, University of Tsukuba

• Iijima Hiroaki

  Tsukuba Medical Center

• Naito Takashi

  Tsukuba Medical Center

• Saito Takefumi

  National Hospital Organization, Ibarakihigashi National Hospital

• Noguchi Emiko

  Department of Medical Genetics, University of Tsukuba

• Konno Satoshi

  First Department of Medicine, Hokkaido University School of Medicine

• Nishimura Masaharu

  First Department of Medicine, Hokkaido University School of Medicine

• Hirota Tomomitsu

  Laboratory for Respiratory and Allergic Diseases, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN)

• Tamari Mayumi

  Laboratory for Respiratory and Allergic Diseases, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN)

• Hizawa Nobuyuki

  Department of Pulmonary Medicine, University of Tsukuba

書誌事項

タイトル別名

• Genetic association of the functional <i>CDHR3</i> genotype with early-onset adult asthma in Japanese populations

抄録

Background: Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma. Methods: We performed a candidate gene case–control association study of 2 independent Japanese populations (a total of 3366 adults). The odds ratios (ORs) for association of the A allele at rs6967330 with adult asthma were calculated according to age at onset of asthma. In addition, the effect of the CDHR3 genotype on the development of specific asthma phenotypes was examined. Results: The A allele was associated with asthma (OR = 1.56; Mantel–Haenszel p = 0.0040) when the analysis was limited to patients with early-onset adult asthma. In addition, when the analysis was limited to atopic individuals, a stronger association of the CDHR3 variant with early-onset asthma was found, and interaction of the CDHR3 genotype with atopy was demonstrated. Finally, a significant association of this variant was specifically found with a phenotype of asthma characterized by atopy, early-onset, and lower lung function. Conclusions: Our study supports the concept that the CDHR3 variant is an important susceptibility factor for severe adult asthma in individuals who develop the disease in early life. The interaction between the CDHR3 variant and atopy indicates that genetic predisposition to early respiratory viral infection is combined with atopy in promoting asthma.

収録刊行物

• Allergology International

  Allergology International 66 (4), 563-567, 2017

  一般社団法人日本アレルギー学会

キーワード

• Asthma phenotype
• Cadherin-related family member 3 (CDHR3)
• Early-onset asthma
• Genetics
• Human rhinovirus C

詳細情報

• CRID: 1390001204631138816
• NII論文ID: 130006179446
• NII書誌ID: AA11091750
• DOI: 10.1016/j.alit.2017.02.012
• ISSN: 14401592
• ISSN: 13238930
• HANDLE: 2241/00159690
• Web Site: https://tsukuba.repo.nii.ac.jp/records/54267
• Web Site: https://api.elsevier.com/content/article/PII:S1323893017300163?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893017300163?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2018302405
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
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