Genetic association of the functional <i>CDHR3</i> genotype with early-onset adult asthma in Japanese populations





<p><i>Background</i>: Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (<i>CDHR3</i>), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma.</p><p><i>Methods</i>: We performed a candidate gene case–control association study of 2 independent Japanese populations (a total of 3366 adults). The odds ratios (ORs) for association of the A allele at rs6967330 with adult asthma were calculated according to age at onset of asthma. In addition, the effect of the <i>CDHR3</i> genotype on the development of specific asthma phenotypes was examined.</p><p><i>Results</i>: The A allele was associated with asthma (OR = 1.56; Mantel–Haenszel <i>p</i> = 0.0040) when the analysis was limited to patients with early-onset adult asthma. In addition, when the analysis was limited to atopic individuals, a stronger association of the <i>CDHR3</i> variant with early-onset asthma was found, and interaction of the <i>CDHR3</i> genotype with atopy was demonstrated. Finally, a significant association of this variant was specifically found with a phenotype of asthma characterized by atopy, early-onset, and lower lung function.</p><p><i>Conclusions</i>: Our study supports the concept that the <i>CDHR3</i> variant is an important susceptibility factor for severe adult asthma in individuals who develop the disease in early life. The interaction between the <i>CDHR3</i> variant and atopy indicates that genetic predisposition to early respiratory viral infection is combined with atopy in promoting asthma.</p>


  • Allergology International

    Allergology International 66(4), 563-567, 2017