Phenotypic analysis of asthma in Japanese athletes

• Tsukioka Keisuke

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Koya Toshiyuki

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Ueno Hiroshi

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Hayashi Masachika

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Sakagami Takuro

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

• Hasegawa Takashi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• Arakawa Masaaki

  Niigata Institute for Health and Sports Medicine

• Suzuki Eiichi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• Kikuchi Toshiaki

  Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences

抄録

Background: Asthma in athlete populations such as Olympic athletes has various pathogeneses. However, few reports are available on the features of asthma in the athlete population in clinical practice. In this study, we focused on classifying asthma in Japanese athlete population. Methods: We performed a cluster analysis of data from pulmonary function tests and clinical biomarkers before administering inhaled corticosteroids (ICS) therapy in athlete population of individuals diagnosed with asthma (n = 104; male, 76.9%; median age, 16.0 years), based on respiratory symptoms and positive data on methacholine provocation tests. We also compared backgrounds, sports types, and treatments between clusters. Results: Three clusters were identified. Cluster 1 (32%) comprised athletes with a less atopic phenotype and normal pulmonary function. Cluster 2 (44%) comprised athletes with a less atopic phenotype and lower percent predicted forced expiratory volume in 1 s (%FEV₁) values, despite less symptomatic state. Cluster 3 (24%) comprised athletes with a strong atopic phenotype such as high eosinophil count in the blood and total serum immunoglobulin E level. After treatment with ICS or ICS plus long-acting β-adrenergic receptor agonist for 6–12 months, %FEV₁ values were significantly improved in Cluster 2 athletes, whereas Cluster 3 athletes had a significant decrease in the fraction of exhaled nitric oxide compared to pretreatment values. Conclusions: These data suggest three clusters exist in Japanese athlete population with asthma. Between the clusters, the characteristics differed with regard to symptoms, atopic features, and lower %FEV₁ values. The pathogeneses between clusters may vary depending on the inflammation type and airway hyperresponsiveness.

収録刊行物

• Allergology International

  Allergology International 66 (4), 550-556, 2017

  一般社団法人日本アレルギー学会

キーワード

• Asthma
• Athlete
• Cluster analysis
• Fraction of exhaled nitric oxide
• Methacholine provocation test

詳細情報

• CRID: 1390001204633982848
• NII論文ID: 130006179506
• DOI: 10.1016/j.alit.2017.02.009
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893017300138?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893017300138?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2018302403
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
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