Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population　― The Hisayama Study ―

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  • Sakata Satoko
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Hata Jun
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Fukuhara Masayo
    Division of General Internal Medicine, Kyushu Dental University
  • Yonemoto Koji
    Advanced Medical Research Center, Faculty of Medicine, University of the Ryukyus
  • Mukai Naoko
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Yoshida Daigo
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Kishimoto Hiro
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Ohtsubo Toshio
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kitazono Takanari
    Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kiyohara Yutaka
    Hisayama Research Institute for Lifestyle Diseases
  • Ninomiya Toshiharu
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

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Abstract

<p>Background:The association of morning and evening home blood pressures (HBPs) with carotid atherosclerosis has been uncertain in general populations, so we aimed to investigate it in a general Japanese population.</p><p>Methods and Results:We performed a cross-sectional survey of 2,856 community-dwelling individuals aged ≥40 years to examine the association of morning and evening HBPs with carotid mean intima-media thickness (IMT). The age- and sex-adjusted geometric averages of carotid mean IMT increased significantly with increasing morning HBP (optimal: 0.67 mm; normal: 0.69 mm; high normal: 0.72 mm; grade 1 hypertension: 0.74 mm; and grade 2+3 hypertension: 0.76 mm) and with increasing evening HBP (0.68 mm, 0.71 mm, 0.73 mm, 0.76 mm, and 0.78 mm, respectively) (both P for trend <0.001). These associations remained significant even after adjusting for potential confounding factors. Likewise, both isolated morning hypertension (morning HBP ≥135/85 mmHg and evening HBP <135/85 mmHg) and isolated evening hypertension (evening HBP ≥135/85 mmHg and morning HBP <135/85 mmHg) as well as sustained hypertension (both morning and evening HBP ≥135/85 mmHg) were significantly associated with thicker mean IMT.</p><p>Conclusions:Our findings suggested that both morning and evening HBPs were significantly associated with carotid atherosclerosis in this general Japanese population.</p>

Journal

  • Circulation Journal

    Circulation Journal 81 (11), 1647-1653, 2017

    The Japanese Circulation Society

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