REVIEW FOR THE 2016 SATO AWARD : Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research

• Satoh Kimio

  Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

書誌事項

タイトル別名

• Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research

抄録

Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, activated platelets, and cardiac fibroblasts in response to oxidative stress. Excessive and continuous activation of the RhoA/Rho-kinase system promotes the secretion of CyPA, resulting in the development of multiple cardiovascular diseases. Basigin (Bsg), a transmembrane glycoprotein that activates matrix metalloproteinases, is an extracellular receptor for CyPA that promotes cell proliferation and inflammation. Thus, the CyPA/Bsg system is potentially a novel therapeutic target for cardiovascular diseases. Importantly, plasma CyPA levels are increased in patients with coronary artery disease, abdominal aortic aneurysms, pulmonary hypertension, and heart failure. Moreover, plasma CyPA levels can predict all-cause death in patients with coronary artery disease and pulmonary hypertension. Additionally, plasma soluble Bsg levels are increased and predict all-cause death in patients with heart failure, suggesting that CyPA and Bsg are novel biomarkers for cardiovascular diseases. To discover further novel molecules targeting the CyPA/Bsg system, high-throughput screening of compounds found molecules that ameliorate the development of cardiovascular diseases. In addition to CyPA and Bsg, novel therapeutic targets and their inhibitors for patients with pulmonary arterial hypertension have been recently screened and identified. Ultimately, the final goal is to develop novel biomarkers and medications that will be useful for improving the prognosis and quality of life in patients with cardiovascular diseases.

収録刊行物

• Circulation Journal

  Circulation Journal 81 (11), 1557-1563, 2017

  一般社団法人 日本循環器学会

キーワード

• Atherosclerosis
• Coronary artery disease
• Drug discovery
• Heart failure
• Pulmonary hypertension

詳細情報

• CRID: 1390001205106652416
• NII論文ID: 130006179876
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-17-1029
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 028596257
• PubMed: 28993547
• Web Site: http://id.ndl.go.jp/bib/028596257
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028596257
• Web Site: https://www.jstage.jst.go.jp/article/circj/81/11/81_CJ-17-1029/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018178893
• 本文言語コード: en
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