Hemolytic Uremic Syndrome-associated Encephalopathy Successfully Treated with Corticosteroids Hemolytic Uremic Syndrome-associated Encephalopathy Successfully Treated with Corticosteroids

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Author(s)

    • Hosaka Takashi
    • Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Nakamagoe Kiyotaka
    • Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Tamaoka Akira
    • Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Japan

Abstract

<p>The encephalopathy that occurs in association with hemolytic uremic syndrome (HUS), which is caused by enterohemorrhagic <i>Escherichia coli (E. coli),</i> has a high mortality rate and patients sometimes present sequelae. We herein describe the case of a 20-year-old woman who developed encephalopathy during the convalescent stage of HUS caused by <i>E.</i><i>coli</i> O26. Hyperintense lesions were detected in the pons, basal ganglia, and cortex on diffusion-weighted brain MRI. From the onset of HUS encephalopathy, we treated the patient with methylprednisolone (mPSL) pulse therapy alone. Her condition improved, and she did not present sequelae. Our study shows that corticosteroids appear to be effective for the treatment of some patients with HUS encephalopathy. </p>

Journal

  • Internal Medicine

    Internal Medicine 56(21), 2937-2941, 2017

    Japanese Society of Internal Medicine

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