Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from <i>Dictyostelium discoideum</i>
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- Takahashi Katsunori
- Department of Medical Technology, Faculty of Health Science, Gunma Paz College
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- Kikuchi Haruhisa
- Laboratory of Natural Product Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Nguyen Van Hai
- Laboratory of Natural Product Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Oshima Yoshiteru
- Laboratory of Natural Product Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Ishigaki Hirotaka
- Department of Medical Technology, Faculty of Health Science, Gunma Paz College
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- Nakajima-Shimada Junko
- Department of Molecular and Cellular Parasitology, Graduate School of Health Sciences, Gunma University
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- Kubohara Yuzuru
- Laboratory of Health and Life Science, Graduate School of Heath and Sports Science, Juntendo University
Bibliographic Information
- Other Title
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- Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from Dictyostelium discoideum
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Abstract
<p>Differentiation-inducing factor-3 (DIF-3; 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one), which is found in the cellular slime mold Dictyostelium discoideum, is a potential candidate compound for the development of new medicines; DIF-3 and its derivatives possess several beneficial biological activities, including anti-tumor, anti-Trypanosoma cruzi, and immunoregulatory effects. To assess the relationship between the biological activities of DIF-3 and its chemical structure, particularly in regard to its alkoxy group and the length of the alkyl chains at the acyl group, we synthesized two derivatives of DIF-3, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)octan-1-one (DIF-3(+3)) and 1-(3-chloro-2,6-dihydroxy-4-butoxyphenyl)-hexan-1-one (Hex-DIF-3), and investigated their biological activities in vitro. At micro-molar levels, DIF-3(+3) and Hex-DIF-3 exhibited strong anti-proliferative effects in tumor cell cultures, but their anti-T. cruzi activities at 1 µM in vitro were not as strong as those of other known DIF derivatives. In addition, Hex-DIF-3 at 5 µM significantly suppressed mitogen-induced interleukin-2 production in vitro in Jurkat T cells. These results suggest that DIF-3(+3) and Hex-DIF-3 are promising leads for the development of anti-cancer and immunosuppressive agents.</p>
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 40 (11), 1941-1947, 2017
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679611229056
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- NII Article ID
- 130006191965
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 028602324
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- PubMed
- 29093342
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed