Microstructure Analysis of Immobilized Osteopenia Using Microcomputed Tomography：An <i>In Vivo</i> Study

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  • Koseki Hironobu
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Osaki Makoto
    Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Horiuchi Hidehiko
    Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences
  • Honda Yuichiro
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences Department of Rehabilitation, Nagasaki University Hospital
  • Sasabe Ryo
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences Department of Rehabilitation, Nagasaki University Hospital
  • Sakamoto Junya
    Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences
  • Higuchi Takashi
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Sunagawa Sinya
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Okita Minoru
    Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences

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  • µCTによる不動性骨萎縮の骨微細構造解析
  • mCT ニ ヨル フドウセイ ホネ イシュク ノ ホネ ビサイ コウゾウ カイセキ

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Abstract

<p>Objective：To assess the effects of immobilization on the three-dimensional microstructure of cortical and cancellous bone.</p><p>Methods：Eight-week-old specific-pathogen-free Wistar rats were divided into two groups：the control (n＝12) and immobilized group (n＝12). The hind limbs of the rats in the immobilized group were fixed using orthopedic casts for 4 weeks. The cortical bone at the mid-shaft and the cancellous bone at the distal metaphysis of the femur were analyzed using micro-computed tomography.</p><p>Results：The values of total cross-sectional area, cortical bone area, and cortical thickness in the immobilized group were significantly lower than those in the control group. Meanwhile, the relative bone volume (bone volume/total volume) and mean trabecular thickness in the immobilized group decreased and the structure model index significantly increased compared with the values in the control group (P＜0.05).</p><p>Conclusion：Our rat model can evaluate the effects of load-permitting immobilization. The results of this study indicate that structural changes in immobilized osteopenia-affected bone arise mainly from thinning of the cortex and reduction of cancellous bone volume caused by a reduction of trabecular width.</p>

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