Lipoquality control by phospholipase A₂ enzymes Lipoquality control by phospholipase A<sub>2</sub> enzymes

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Author(s)

    • MURAKAMI Makoto MURAKAMI Makoto
    • Laboratory of Environmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, the University of Tokyo|Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science|AMED-CREST, Japan Agency for Medical Research and Development

Abstract

<p>The phospholipase A<sub>2</sub> (PLA<sub>2</sub>) family comprises a group of lipolytic enzymes that typically hydrolyze the <i>sn</i>-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. The mammalian genome encodes more than 50 PLA<sub>2</sub>s or related enzymes, which are classified into several subfamilies on the basis of their structures and functions. From a general viewpoint, the PLA<sub>2</sub> family has mainly been implicated in signal transduction, producing bioactive lipid mediators derived from fatty acids and lysophospholipids. Recent evidence indicates that PLA<sub>2</sub>s also contribute to phospholipid remodeling for membrane homeostasis or energy production for fatty acid β-oxidation. Accordingly, PLA<sub>2</sub> enzymes can be regarded as one of the key regulators of the quality of lipids, which I herein refer to as <i>lipoquality</i>. Disturbance of PLA<sub>2</sub>-regulated lipoquality hampers tissue and cellular homeostasis and can be linked to various diseases. Here I overview the current state of understanding of the classification, enzymatic properties, and physiological functions of the PLA<sub>2</sub> family.</p>

Journal

  • Proceedings of the Japan Academy, Series B

    Proceedings of the Japan Academy, Series B 93(9), 677-702, 2017

    The Japan Academy

Codes

  • NII Article ID (NAID)
    130006199317
  • NII NACSIS-CAT ID (NCID)
    AA00785485
  • Text Lang
    ENG
  • ISSN
    0386-2208
  • NDL Article ID
    028676198
  • NDL Call No.
    Z53-T495
  • Data Source
    NDL  J-STAGE 
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