強迫症患者における実行機能とNIRSによる脳血流量変化  [in Japanese] Hemodynamic Changes Using Near-Infrared Spectroscopy (NIRS) in Patients with Obsessive Compulsive Disorder  [in Japanese]

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Abstract

<p>本研究は,3つの実行機能課題施行中の前頭葉課題の活動をNIRSによって測定し強迫症患者と健常者の比較検討を行い,強迫症患者における精神症状と前頭葉活動の関係を調べた。対象は,DSM-5によって診断した14名の強迫症患者と,年齢と性別をマッチングした16名の健常者である。ロンドン塔課題及び言語流暢性課題において,課題施行中の脳血流変化量は健常者群に比較して,強迫症患者群において有意に低い変化量であった。また言語流暢性課題においては,左背外側前頭前皮質の脳血流変化量と強迫症状の重症度に負の相関が認められた。同時に構造方程式による解析では,うつ症状や不安症状との関連が認められた。これらから,強迫症の併存症状を含めた病態は,前頭前皮質,特に背外側前頭前皮質の脳血流変化量の異常と関連していることが示唆された。</p>

<p>Few studies have evaluated prefrontal cortex (PFC) activity using near-infrared spectroscopy (NIRS) during the performance of multiple neuropsychological tasks in patients with obsessive-compulsive disorder (OCD). The aims of the current study were 1) to examine the patterns of hemodynamic changes in PFC regions, as measured by NIRS, during various neuropsychological tasks in OCD patients and normal controls, and 2) to clarify the relationship between PFC activity and other comorbid symptoms. Fourteen patients with OCD diagnosed using DSM-5, and 16 age- and gender-matched healthy volunteers were enrolled in this study. Brain activity was measured using NIRS during the administration of several neuropsychological test batteries. We compared hemodynamic changes and psychometric and executive functioning test results between the groups. We also examined the relationships between the variables using structural equation modeling (SEM). The OCD group showed significantly lower activity in the dorso-lateral PFC (DLPFC) during the verbal fluency (VFT) and Tower of London (ToL) tasks. Hemodynamic changes in the left DLPFC during the VFT were negatively correlated with OCD severity. The findings analyzed using SEM indicated that brain activity observed in the specific regions had robust direct or indirect relationships with comorbid symptoms, such as depressive or anxiety status, in the OCD group. The current study supports the view that a variety of psychopathological features observed in OCD patients might be explained by abnormal brain activity in the PFC, particularly in the left DLPFC.</p>

Journal

  • Anxiety Disorder Research

    Anxiety Disorder Research 9(1), 42-49, 2017

    Japanese Society of Anxiety Disorder

Codes

  • NII Article ID (NAID)
    130006201177
  • NII NACSIS-CAT ID (NCID)
    AA12761156
  • Text Lang
    JPN
  • ISSN
    2188-7578
  • NDL Article ID
    029640758
  • NDL Call No.
    Z74-G389
  • Data Source
    NDL  J-STAGE 
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