Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells
-
- Nakamura Takehiro
- Faculty of Pharmaceutical Sciences, Tokyo University of Science Faculty of Pharmacy, Kindai University
-
- Yoshida Eiko
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
-
- Fujie Tomoya
- Faculty of Pharmaceutical Sciences, Toho University
-
- Ogata Fumihiko
- Faculty of Pharmacy, Kindai University
-
- Yamamoto Chika
- Faculty of Pharmaceutical Sciences, Toho University
-
- Kawasaki Naohito
- Faculty of Pharmacy, Kindai University
-
- Kaji Toshiyuki
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
この論文をさがす
抄録
<p>Organic-inorganic hybrid molecules, which are composed of organic-ligand(s) and metal(s), are indispensable as synthetic reagents in chemistry, but they have made very little in the way of contributions to biological research. Previously, we reported that the cytotoxicity of organic-inorganic hybrid molecules in vascular endothelial cells depends on interactions between the intramolecular metal and ligand, but remains independent of the hydrophobicity of the intramolecular metal(s). Herein, we show a synergistic cytotoxicity produced by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in vascular endothelial cells that depends on the intracellular accumulation of copper.</p>
収録刊行物
-
- The Journal of Toxicological Sciences
-
The Journal of Toxicological Sciences 42 (6), 683-687, 2017
一般社団法人 日本毒性学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204905100928
-
- NII論文ID
- 130006206268
-
- NII書誌ID
- AN00002808
-
- ISSN
- 18803989
- 03881350
-
- NDL書誌ID
- 028715506
-
- PubMed
- 29142167
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可