INCIDENCE AND RISK FACTORS OF DELAYED REACTIONS AFTER AUTOLOGOUS BLOOD DONATION

• Suzuki Keijiro

  Department of Laboratory Medicine, Iwate Medical University School of Medicine

• Odawara Sho

  Division of Central Clinical Laboratory, Iwate Medical University Hospital

• Takadate Junko

  Division of Central Clinical Laboratory, Iwate Medical University Hospital

• Sasaki Sakiko

  Division of Central Clinical Laboratory, Iwate Medical University Hospital

• Goto Kenji

  Division of Central Clinical Laboratory, Iwate Medical University Hospital

• Kimura Miyoko

  Nursing Department, Iwate Medical University Hospital

• Muramatsu Kyoko

  Nursing Department, Iwate Medical University Hospital

• Suwabe Akira

  Department of Laboratory Medicine, Iwate Medical University School of Medicine

Bibliographic Information

Other Title

• 自己血採血後の遅発性副作用の発生率と危険因子

Abstract

Delayed reactions (DRs) occurring after autologous blood donation are recognized as off-site adverse reactions associated with fainting and severe injury, but DR incidence and risk factors remain unclear. To assess DR rates and risk factors, we retrospectively investigated 294 patients after their initial autologous donation at our hospital. We defined DRs as occurring outside the transfusion department, but within one week following autologous donation. After DR rates and patient characteristics were collated, multivariate logistic regression analyses were conducted to identify the factors associated with DRs. The DR prevalence was 33.7% (99/294 patients). Patients reported DRs most frequently on the day of blood donation (26.9%, 79/294). Many patients with DRs complained of headache, lightheadedness, fatigue, or dizziness. Most symptoms had improved by the fourth day after autologous donation. DRs were associated with the female sex (odds ratio [OR] 2.72, 95% confidence interval [CI] 1.22–6.05), low estimated blood volume (<3,300 ml: OR 2.58, 95%CI 1.01–6.58; 3,300-3,899 ml: OR 2.66, 95%CI 1.13–6.23), and high pre-donation pulse rate (75–89 beats/min: OR 2.08, 95%CI 1.13–3.86). These results suggest that changes in circulation dynamics and modulation of autonomic nerve system components associated with autologous donation are related to DR occurrence.

Journal

• Japanese Journal of Transfusion and Cell Therapy

  Japanese Journal of Transfusion and Cell Therapy 63 (5), 691-699, 2017

  The Japan Society of Transfusion Medicine and Cell Therapy

Keywords

• autologous blood transfusion
• donor sex
• estimated blood volume
• pulse rate

Details

• CRID: 1390001205270840960
• NII Article ID: 130006210669
• DOI: 10.3925/jjtc.63.691
• ISSN: 18830625
• ISSN: 18813011
• Web Site: https://www.jstage.jst.go.jp/article/jjtc/63/5/63_691/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018059729
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed