Association of Airflow Limitation With Carotid Atherosclerosis in a Japanese Community　― The Hisayama Study ―

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  • Kudo Kunihiro
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
  • Hata Jun
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Matsumoto Koichiro
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
  • Shundo Yuki
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
  • Fukuyama Satoru
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
  • Inoue Hiromasa
    Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University
  • Kitazono Takanari
    Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
  • Kiyohara Yutaka
    Hisayama Research Institute for Lifestyle Diseases
  • Ninomiya Toshiharu
    Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
  • Nakanishi Yoichi
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University

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<p>Background:There has been no large-scale observational study examining the association between chronic obstructive pulmonary disease (COPD) or airflow limitation and carotid atherosclerosis in the general population across a wide range of generations in Asia. In the present study we assessed the association between airflow limitation and carotid intima-media thickness (IMT) in a general Japanese population, with consideration of a comprehensive array of cardiovascular risk factors.</p><p>Methods and Results:In all, 2,099 community-dwelling Japanese subjects were included in the study. Airflow limitation was defined by spirometry. Maximum and mean IMT values were measured using carotid ultrasonography. Among the subjects, 352 (16.8%) had airflow limitation. The geometric mean values of maximum IMT and mean IMT were significantly higher in subjects with than without airflow limitation (1.27 vs. 1.18 mm, respectively, for maximum IMT; 0.73 mm vs. 0.72 mm, respectively, for mean IMT) and increased with the severity of airflow limitation after adjustment for conventional risk factors, including smoking habits and serum high-sensitivity C-reactive protein. It should be noted that the magnitude of these associations was greater in the middle-aged (40–64 years) than elderly (≥65 years) subgroup.</p><p>Conclusions:The findings of the present study suggest that airflow limitation is a significant risk factor for carotid atherosclerosis, especially in midlife, in the general Japanese population.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (12), 1846-1853, 2017

    一般社団法人 日本循環器学会

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