Advances in pulmonary research toward generating a respiratory system

• TADOKORO Tomomi

  Department of Regenerative Medicine, Yokohama City University School of Medicine

Bibliographic Information

Other Title

• 呼吸器系組織の創出へ向けた基礎研究の進展

Abstract

The respiratory system is a highly branched organ composed of trachea, bronchioles, and alveoli. Because its main function is the exchange of oxygen and carbon dioxide, respiratory dysfunction can be life threatening. In fact, respiratory disease is a leading cause of death worldwide. Therefore regenerative medicine of the respiratory system is getting more attention, and many researches to reconstitute the respiratory system using pluripotent stem cells or somatic stem cells have been reported. This review summarizes the development of the respiratory system and advances in the tracheal/bronchiolar/lung stem cells and cell culture technology, including 3-D organoids. In conclusion, we also discuss challenges to make regenerative medicine suitable for practical use.

Journal

• Japanese Journal of Transplantation

  Japanese Journal of Transplantation 52 (4-5), 339-345, 2017

  The Japan Society for Transplantation

Keywords

• induced pluripotent stem cells (iPSCs)
• 3-D organoids
• development of the respiratory system
• tracheal/bronchiolar/lung stem cells

Details

• CRID: 1390001205510248832
• NII Article ID: 130006219180
• DOI: 10.11386/jst.52.4-5_339
• ISSN: 21880034
• ISSN: 05787947
• Web Site: https://search.jamas.or.jp/link/ui/2018078134
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed