セツキシマブ+FP併用療法が奏効し根治を目指した手術が可能になった症例  [in Japanese] Cetuximab+FP therapy may enable radical resection of metastases in patients with tongue small cell carcinoma  [in Japanese]

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Author(s)

    • 鳴瀬 智史 Naruse Tomofumi
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 柳本 惣市 Yanamoto Souichi
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 川北 晃子 Kawakita Akiko
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 六反田 賢 Rokutanda Satoshi
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 大谷 昇平 Otani Shohei
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences
    • 梅田 正博 Umeda Masahiro
    • 長崎大学大学院医歯薬学総合研究科展開医療科学講座口腔腫瘍治療学分野 Department of Clinical Oral Oncology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences

Abstract

今回われわれは,切除困難な舌小細胞癌頸部リンパ節転移に対し,セツキシマブ+FP併用療法施行後,局所切除が可能となった1例を経験したので報告する。<br>患者は74歳男性。右側舌と右顎下部の腫瘤形成を主訴に当科を受診した。画像検査で内頸動脈を広範囲に取り巻く右ルビエールリンパ節転移があり,切除困難例と判断し,セツキシマブ+FP併用療法を施行した。<br>全身療法施行後,左側根治的頸部郭清術変法,下顎区域切除を含む腫瘍切除術に加え,咽頭後リンパ節郭清を施行した。術後はS-1併用放射線療法を施行したが,術後9ヶ月で頸部および肺に腫瘤性病変がみられたため,頸部腫瘤の切除術を施行し,小細胞癌の確定診断を得た。姑息的化学療法を施行するも奏効せず,術後1年7ヶ月に永眠となった。

We describe our experience with a case of enabled radical resection after cetuximab+FP therapy in a patient who presented with unresectable metastasis of tongue small cell carcinoma.<br>A 74-year-old man was referred to our hospital for evaluation of right tongue and submandibular masses. Imaging also identified a right Rouviere lymph node lesion involving the cavernous internal carotid artery. Owing to the node's location, it was unresectable, so the patient received cetuximab+FP therapy.<br>After biochemotherapy, the patient underwent left modified radical neck dissection and tumor resection including segmental mandibulotomy and retropharyngeal lymph node dissection. Additionally, the patient was treated with radiation with concurrent S-1.<br>Nine months after tumor resection, recurrence was noted in the left upper neck and new lung lesions were identified. A pathological examination revealed small cell carcinoma. Palliative chemotherapy including etoposide administration was implemented. The lung mass was resistant to this therapy and the patient died 19 months after his initial resection procedure.

Journal

  • Toukeibu Gan

    Toukeibu Gan 43(3), 377-382, 2017

    Japan Society for Head and Neck Cancer

Codes

  • NII Article ID (NAID)
    130006219590
  • Text Lang
    JPN
  • ISSN
    1349-5747
  • Data Source
    J-STAGE 
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