Outcomes of the Re-classification of WHO Class IV Lupus Nephritis Using the ISN/RPS Classification: a Single Center Retrospective Observational Study from the JUDE Study

DOI Web Site Web Site 参考文献22件
  • MIYASHITA TOMOKO
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine
  • MORIMOTO SHINJI
    Department of Internal Medicine and Rheumatology, Juntendo University Urayasu Hospital
  • HONDA DAISUKE
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine
  • NAKANO SOUICHIRO
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine
  • AMANO HIROFUMI
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine
  • OSAWA ISAO
    Division of Nephrology, Saiyuu-souka Hospital
  • YAMAJI KEN
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine
  • TOMINO YASUHIKO
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine
  • TAKASAKI YOSHINARI
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine
  • TAMURA NAOTO
    Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine

この論文をさがす

抄録

<p>Objective: The International Society of Nephrology-Renal Pathology Society (ISN/RPS) 2003 classification of lupus nephritis (LN) was designed to provide beneficial pathologic information relevant to the renal outcome. We conducted a retrospective observational study to investigate the baseline characteristics and renal response to treatment for patients with LN, comparing the World Health Organization (WHO) and ISN/RPS classification systems.</p><p>Materials: A total of 39 Japanese patients (2 men; 37 women) with LN who underwent percutaneous needle renal biopsy between 1998 and 2012 were evaluated.</p><p>Methods: Renal biopsy samples were classified using the 1995 WHO and 2003 ISN/RPS criteria.</p><p>Results: Among WHO class IV patients, a higher number of patients reclassified into ISN/RPS class III achieved complete response to treatment compared to those reclassified into class IV at 6 months follow-up. Twenty patients in WHO class IVc were reclassified into ISN/RPS classes III, III+V, IV-S, IV-S+V, IV-G and IV-G+V. No patients developed end-stage renal failure requiring renal replacement therapy.</p><p>Conclusions: The results suggest that the ISN/RPS classification system is more advantageous in predicting renal outcome and guiding treatment, especially for those previously classified with WHO class IVc LN.</p>

収録刊行物

参考文献 (22)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ