A pilot study of gemcitabine and paclitaxel as third-line chemotherapy in metastatic urothelial carcinoma
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- Naiki Taku
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan Department of Urology, Anjo Kosei Hospital, Japan
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- Iida Keitaro
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Kawai Noriyasu
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Etani Toshiki
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Ando Ryosuke
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Nagai Takashi
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan Department of Urology, Anjo Kosei Hospital, Japan
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- Tanaka Yutaro
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Hamamoto Shuzo
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Hamakawa Takashi
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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- Akita Hidetoshi
- Department of Urology, Anjo Kosei Hospital, Japan
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- Sugiyama Yosuke
- Department of Pharmacy, Nagoya City University Hospital, Japan
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- Yasui Takahiro
- Department of Nephro-Urology, Nagoya City University, Graduate School of Medical Sciences, Japan
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Abstract
<p>Background: We evaluated the effectiveness of gemcitabine and paclitaxel therapy in patients with metastatic urothelial carcinoma for whom two lines of sequential chemotherapy had been unsuccessful.</p><p>Methods: A total number of 105 patients who had previously received first-line chemotherapy consisting of gemcitabine and cisplatin or carboplatin, were treated with second-line gemcitabine and docetaxel therapy between June 2006 and May 2015. Of these patients, 15 with an Eastern Cooperative Oncology Group Performance Status of 0 or 1 were administered gemcitabine and paclitaxel as third-line treatment from 2013 after failure of the second-line therapy. For each 21-day cycle, gemcitabine (1000 mg/m2) was administered on days 1, 8, and 15, and paclitaxel (200 mg/m2) on day 1. Patients were assessed for each cycle and any adverse events were noted. Furthermore, a Short Form Health Survey questionnaire was used to assess each patient’s quality of life.</p><p>Results: Third-line gemcitabine and paclitaxel treatment cycles were undertaken for a median of four times (range 2–9). The disease control rate was 80.0%. After second-line gemcitabine and docetaxel therapy was completed, median progression-free survival and median overall survival were determined as 9.8 and 13.0 months, respectively. The only prognostic factor for overall survival, as determined by univariate and multivariate analyses, was third-line gemcitabine and paclitaxel therapy. Neutropenia (66.7%) and thrombocytopenia (53.3%) were noted as the grade 3 treatment-related toxicities. After two cycles of third-line gemcitabine and paclitaxel therapy, the pre- and post-treatment quality of life scores did not differ significantly.</p><p>Conclusions: Results demonstrate that third-line combination therapy using gemcitabine and paclitaxel is a feasible option for metastatic urothelial carcinoma patients.</p>
Journal
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- Journal of Rural Medicine
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Journal of Rural Medicine 12 (2), 105-111, 2017
THE JAPANESE ASSOCIATION OF RURAL MEDICINE
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Details 詳細情報について
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- CRID
- 1390282680231715584
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- NII Article ID
- 130006233678
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- DOI
- 10.2185/jrm.2940
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- ISSN
- 18804888
- 1880487X
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed