Possible Involvement of Surface Antigen Protein 2 in the Morphological Transition and Biofilm Formation of <I>Candida albicans</I>
-
- Okamoto-Shibayama Kazuko
- Department of Microbiology, Tokyo Dental College
-
- Kikuchi Yuichiro
- Department of Microbiology, Tokyo Dental College
-
- Kokubu Eitoyo
- Department of Microbiology, Tokyo Dental College
-
- Ishihara Kazuyuki
- Department of Microbiology, Tokyo Dental College
Bibliographic Information
- Other Title
-
- Possible Involvement of Surface Antigen Protein 2 in the Morphological Transition and Biofilm Formation of Candida albicans
Search this article
Abstract
Surface antigen protein 2 (Csa2) is a member of the Candida albicans Common in Fungal Extracellular Membranes (CFEM) protein superfamily. We previously established its role in iron acquisition in C. albicans. However, the other roles of Csa2 remain unknown. Here, we compared growth, morphological transition, and biofilm formation among wild-type, Csa2-mutant, and complemented strains of C. albicans. Deletion of the Csa2 gene resulted in smaller and reduced colony growth, significant attenuation of the dimorphic transition under serum-inducing conditions, and reduced biofilm formation; complementation restored these levels to those of the wild-type. Our findings demonstrated that Csa2 participated in yeast-to-hyphae morphological switching under serum-inducing conditions and contributed to the biofilm formation of C. albicans. This work, therefore, provides novel insights into the potential roles of Csa2 in virulence of C. albicans.
Journal
-
- Medical Mycology Journal
-
Medical Mycology Journal 58 (4), E139-E143, 2017
The Japanese Society for Medical Mycology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205398027776
-
- NII Article ID
- 130006233737
-
- NII Book ID
- AA12518136
-
- ISSN
- 2186165X
- 18820476
- 21856486
-
- NDL BIB ID
- 028624968
-
- PubMed
- 29187716
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed