Highlighted Paper selected by Editor-in-Chief : Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database

• Nakao Satoshi

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Hatahira Haruna

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Sasaoka Sayaka

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Hasegawa Shiori

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Motooka Yumi

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Ueda Natsumi

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Abe Junko

  Laboratory of Drug Informatics, Gifu Pharmaceutical University Medical Database Co., Ltd.

• Fukuda Akiho

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Naganuma Misa

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

• Kanoh Hiroyuki

  Department of Dermatology, Gifu University Graduate School of Medicine, Gifu University

• Seishima Mariko

  Department of Dermatology, Gifu University Graduate School of Medicine, Gifu University

• Ishiguro Motoyuki

  Ishiguro Clinic

• Kinosada Yasutomi

  United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University

• Nakamura Mitsuhiro

  Laboratory of Drug Informatics, Gifu Pharmaceutical University

書誌事項

タイトル別名

• Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database

抄録

Drug-induced photosensitivity (DIP) refers to the development of cutaneous disorders caused by the combined effects of different medications and light. The aim of this study was to obtain new information on drug risk comparisons and on DIP onset profiles, including seasonal variations, for clinically used prescription drugs. We analyzed reports of DIP recorded in the Japanese Adverse Drug Event Report (JADER) database using a reporting odds ratio (ROR). We also used Weibull proportional-hazards models for each drug to examine the patterns of DIP. The JADER database contains 430587 reports recorded from April 2004 to November 2016. The ROR values (95% confidence interval [CI]) of losartan/hydrochlorothiazide (HCTZ), valsartan/HCTZ, and ketoprofen were 214.5 (162.1–283.9), 104.7 (66.3–165.5), and 117.9 (76.6–181.5), respectively. For time-to-onset analysis, the median durations (interquartile range) for DIP caused by losartan/HCTZ, valsartan/HCTZ, and ketoprofen were 56 (41–78), 49 (38–88), and 8 (2–14) days, respectively. The lower limit of the 95% CI for the Weibull shape parameter β value for losartan/HCTZ was greater than 1. More than half of the reports of DIP onset following the administration of ketoprofen were recorded within 10 d of treatment initiation. The seasonal variation of photosensitivity reactions was shown to follow an annual sinusoidal pattern with a peak in April and May. Based on the results, losartan/HCTZ, valsartan/HCTZ, and ketoprofen should be used carefully in clinical practice to avoid DIP.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 40 (12), 2158-2165, 2017

  公益社団法人 日本薬学会

キーワード

• photosensitivity
• Japanese Adverse Drug Event Report database
• seasonal variation
• ketoprofen
• hydrochlorothiazide

詳細情報

• CRID: 1390282679609122176
• NII論文ID: 130006235449
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b17-00561
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 028676279
• PubMed: 29199239
• Web Site: http://id.ndl.go.jp/bib/028676279
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028676279
• Web Site: https://www.jstage.jst.go.jp/article/bpb/40/12/40_b17-00561/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018244015
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可