マウス急性移植片対宿主病モデルに対する脱分化脂肪細胞移植の治療効果  [in Japanese] Effect of Dedifferentiated Fat Cell Transplantation in a Mouse Model of Acute Graft-Versus-Host Disease  [in Japanese]

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Author(s)

    • 村井 健美 Murai Takemi
    • 日本大学医学部小児科学系小児科学分野 Department of Pediatrics and Child Health, Nihon University School of Medicine
    • 松本 太郎 Matsumoto Taro
    • 日本大学医学部機能形態学系細胞再生・移植医学分野 Department of Functional Morphology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine
    • 石毛 美夏 Ishige Mika
    • 日本大学医学部小児科学系小児科学分野 Department of Pediatrics and Child Health, Nihon University School of Medicine
    • 風間 智彦 Kazama Tomohiko
    • 日本大学医学部機能形態学系細胞再生・移植医学分野 Department of Functional Morphology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine
    • 加野 浩一郎 Kano Koichiro
    • 日本大学生物資源科学部応用生物科学科 Laboratory of Cell and Tissue Biology, College of Bioresource Science, Nihon University

Abstract

移植片対宿主病 (graft versus host disease: GVHD) は造血幹細胞移植 (hematopoietic cell transplantation: HCT) の致死的合併症の一つとして知られている.近年ステロイド抵抗性急性GVHD に対し間葉系幹細胞 (mesenchymal stem cell: MSC) を用いた細胞治療の臨床応用が始まっている. 脱分化脂肪細胞 (dedifferentiated fat cell: DFAT) にはMSC と同様の免疫調節作用があることが確認されており,DFAT をGVHD の治療に応用できる可能性がある.本検討ではマウス急性GVHD モデルを作製し,尾静脈からDFAT を投与し治療効果を検討した.DFAT を投与すると生存率が改善傾向を示し,体重減少が抑制され,臨床スコアが改善した.本検討により,DFAT が急性GVHD の細胞治療のソースとなりうることを示した.

Graft-versus-host disease (GVHD) is known to be one of the lethal complications of hematopoietic cell transplantation (HCT). Recently, cell therapy using mesenchymal stem cells (MSC) has been applied clinically for steroid-resistant acute GVHD. Since it has been confirmed that dedifferentiated fat cells (DFAT) possess immunomodulatory effects that are similar to MSC, these cells have the potential to be applied to the treatment of GVHD. In this study, we evaluated the effect of intravenous administration of DFAT cells in a mouse model of acute GVHD. We found that the administration of DFAT cells tended to improve survival, suppressed weight loss and improved the clinical score of the GVHD mice. These findings suggest that DFAT cells could become a new cell source for the treatment of acute GVHD.

Journal

  • Journal of Nihon University Medical Association

    Journal of Nihon University Medical Association 76(5), 187-194, 2017

    NIHON UNIVERSITY MEDICAL ASSOCIATION

Codes

  • NII Article ID (NAID)
    130006236544
  • NII NACSIS-CAT ID (NCID)
    AN0018408X
  • Text Lang
    JPN
  • Journal Type
    大学紀要
  • ISSN
    0029-0424
  • NDL Article ID
    028649036
  • NDL Call No.
    Z19-263
  • Data Source
    NDL  J-STAGE 
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