Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

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著者

    • Honda Fumika
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Hirota Tomoya
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Kondo Yuya
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Matsumoto Isao
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Sumida Takayuki
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Tsuboi Hiroto
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Toko Hirofumi
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Ohyama Ayako
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Takahashi Hidenori
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Abe Saori
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Yokosawa Masahiro
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Asashima Hiromitsu
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan
    • Hagiwara Shinya
    • Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan

抄録

<p>Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 56(24), 3373-3377, 2017

    一般社団法人 日本内科学会

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