The interface between the immune system and autonomic nervous system
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- NAKANE Shunya
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University Asian Neurological Intractable Diseases Research and Clinic (AIDReC), Graduate School of Medical Sciences, Kumamoto University
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- MUKAINO Akihiro
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital
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- ANDO Yukio
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
Bibliographic Information
- Other Title
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- 免疫系と自律神経系のインターフェース
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Abstract
<p> The nervous system and the immune system are two major systems in human body. Although it was revealed these two systems correlated, the control of immune cell dynamics by the nervous system has come to draw a lot of attention at the present time. Recent advances in basic and preclinical science reveal that reflex neural circuits inhibit the production of cytokines and inflammation in several animal models. One well-characterized cytokine-inhibiting mechanism, termed the “inflammatory reflex”, is dependent upon vagus nerve stimulation that inhibits cytokine production and attenuates the inflammation. And the mechanism for controlling lymphocyte trafficking becomes clear, and molecular basis of immune regulation by the nervous system was reported. On the other hand, the nervous system is protected from the invasion of harmful agents by the barrier. However, there are neuroimmunological disorders, which is associated with autoimmunity, tumor immunity, and infection immunity. Autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder that leads to widespread autonomic manifestations, in which autoantibodies to ganglionic nicotinic acetylcholine receptors play a central role. Previously, we elucidated the prevalence of extra-autonomic manifestations in patients with AAG. It is necessary to establish the new systems for the detection of autoantibodies to other subunits of acetylcholine receptor.</p>
Journal
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- Japanese Journal of Clinical Immunology
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Japanese Journal of Clinical Immunology 40 (5), 352-360, 2017
The Japan Society for Clinical Immunology
