Expression of Ror2 Associated with Fibrosis of the Submandibular Gland

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Author(s)

Abstract

<p>The submandibular gland (SMG) is one of the major salivary glands that play important roles for variety of physiological functions, such as digestion of foods, prevention of infection, and lubrication of the mouth. Dysfunction of the SMG, often associated with a salivary inflammation, adversely influences a person's quality of life. However, the mechanism underlying inflammation-driven dysfunction of the SMG is largely unknown. Here, we used a mouse model in which the main excretory duct of the SMG is ligated unilaterally to induce inflammation of the gland and examined the expression of <i>Wnt5a</i>, <i>Ror1</i> and <i>Ror2</i> genes, encoding Wnt5a ligand and its cognate receptors, which have been implicated in tissue damage or inflammatory responses in variety of tissues. We show that expression levels of <i>Ror1</i>, <i>Ror2</i>, and <i>Wnt5a</i> are increased in the ligated SMG undergoing interstitial fibrosis, which is accompanied by robust expression of fibrosis-associated genes, such as <i>TGF-β1</i>, <i>TNF-α</i>, <i>IL-1β</i>, and <i>MMP-2</i>. Increased immunostaining signal of Ror2 was detected in the fibrotic tissues with abundant accumulation of fibroblasts and collagen fibers in the ligated SMG, suggesting that Ror2-mediated signaling might be activated in response to tissue damage and associated with progression of fibrosis in the SMG.</p><p>Key words: submandibular gland, Ror2, Wnt5a, fibrosis, inflammation</p>

Journal

  • Cell Structure and Function

    Cell Structure and Function 42(2), 159-167, 2017

    Japan Society for Cell Biology

Codes

  • NII Article ID (NAID)
    130006258840
  • NII NACSIS-CAT ID (NCID)
    AA0060007X
  • Text Lang
    ENG
  • ISSN
    0386-7196
  • NDL Article ID
    028921384
  • NDL Call No.
    Z53-V38
  • Data Source
    NDL  J-STAGE 
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