Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load

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Author(s)

    • SAJIKI Yamato
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • MEKATA Hirohisa
    • Organization for Promotion of Tenure Track, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan|Center for Animal Disease Control, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
    • HORII Yoichiro
    • Center for Animal Disease Control, University of Miyazaki, 1-1 Gakuen Kibanadai-nishi, Miyazaki 889-2192, Japan
    • MURATA Shiro
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • OHASHI Kazuhiko
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • KONNAI Satoru
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • NISHIMORI Asami
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • OKAGAWA Tomohiro
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • MAEKAWA Naoya
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • GOTO Shinya
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • NAGANO Masashi
    • Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan
    • KOHARA Junko
    • Animal Research Center, Agricultural Research Department, Hokkaido Research Organization, Shintoku, Hokkaido 081-0038, Japan
    • KITANO Nana
    • Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan

Abstract

<p>Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infection. The purpose of this study was to confirm intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery. BLV was detected in cord and placental blood, and the BLV in the newborns showed 100% nucleotide identity with the BLV-<i>env</i> sequence from the dams. Notably, a newborn was seropositive for BLV but had no colostral antibodies. In this study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.</p>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 79(12), 2036-2039, 2017

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130006267604
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0916-7250
  • Data Source
    IR  J-STAGE 
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