Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation

• Ebana Yusuke

  Life Science and Bioethics Research Center, Tokyo Medical and Dental University

• Nitta Junichi

  Cardiovascular Division, Saitama Red Cross Hospital

• Takahashi Yoshihide

  Cardiovascular Division, National Disaster Medical Center

• Miyazaki Shinsuke

  Cardiovascular Division, Tsuchiura Kyodo Hospital

• Suzuki Masahito

  Cardiovascular Division, Saitama Red Cross Hospital

• Liu Lian

  Department of Bioinformational Pharmacology, Tokyo Medical and Dental University

• Hirao Kenzo

  Heart Rhythm Center, Tokyo Medical and Dental University

• Kanda Eiichiro

  Department of Nephrology, Tokyo Kyosai Hospital

• Isobe Mitsuaki

  Department of Cardiovascular Medicine, Tokyo Medical and Dental University

• Furukawa Tetsushi

  Department of Bioinformational Pharmacology, Tokyo Medical and Dental University

Abstract

Background:Atrial fibrillation (AF) can be initiated from arrhythmogenic foci within the muscular sleeves that extend not only into the pulmonary veins but also into both vena cavae. The superior vena cava (SVC) is a key target site for catheter ablation. Patients with SVC-derived AF often lack the clinical risk factors of AF. Methods and Results:We conducted a meta-analysis of the clinical and genetic factors of 2,170 AF patients with and without SVC arrhythmogenicity. In agreement with previous reports, the left atrial diameter was smaller in AF patients with SVC arrhythmogenicity. Among 6 variants identified in a previous genome-wide association study in Japanese patients, rs2634073 and rs6584555 were associated with SVC arrhythmogenicity. This finding was confirmed in our meta-analysis using independent cohorts. We also found that SVC arrhythmogenicity was conditionally dependent on age, body mass index, and left ventricular ejection fraction. Conclusions:Both clinical and genetic factors are associated with SVC arrhythmogenicity.

Journal

• Circulation Journal

  Circulation Journal 82 (1), 71-77, 2018

  The Japanese Circulation Society

Keywords

• Atrial fibrillation
• Meta-analysis
• Single-nucleotide polymorphism
• Superior vena cava arrhythmogenicity

Details

• CRID: 1390282680083089152
• NII Article ID: 130006281956
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-17-0350
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 028734629
• PubMed: 28804107
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028734629
• Web Site: https://www.jstage.jst.go.jp/article/circj/82/1/82_CJ-17-0350/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed