人工生合成系を活用した擬天然物創製戦略

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タイトル別名
  • Elaboration of Pseudo-natural Products Using Artificial <i>In Vitro</i> Biosynthesis Systems
  • ジンコウ セイゴウセイケイ オ カツヨウ シタ ギテンネンブツ ソウセイ センリャク

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抄録

 Peptidic natural products often consist of not only proteinogenic building blocks but also unique non-proteinogenic structures such as macrocyclic scaffolds and N-methylated backbones. Since such non-proteinogenic structures are important structural motifs that contribute to diverse bioactivity, we have proposed that peptides with non-proteinogenic structures should be attractive candidates as artificial bioactive peptides mimicking natural products, or so-called pseudo-natural products. We previously devised an engineered translation system for pseudo-natural peptides, referred to as the flexible in vitro translation (FIT) system. This system enabled “one-pot” synthesis of highly diverse pseudo-natural peptide libraries, which can be rapidly screened by mRNA display technology for the discovery of pseudo-natural peptides with diverse bioactivities.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 138 (1), 55-61, 2018-01-01

    公益社団法人 日本薬学会

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