Elaboration of Pseudo-natural Products Using Artificial <i>In Vitro</i> Biosynthesis Systems

• Goto Yuki

  Department of Chemistry, Graduate School of Science, The University of Tokyo

Bibliographic Information

Other Title

• 人工生合成系を活用した擬天然物創製戦略
• ジンコウ セイゴウセイケイ オ カツヨウ シタ ギテンネンブツ ソウセイ センリャク

Abstract

 Peptidic natural products often consist of not only proteinogenic building blocks but also unique non-proteinogenic structures such as macrocyclic scaffolds and N-methylated backbones. Since such non-proteinogenic structures are important structural motifs that contribute to diverse bioactivity, we have proposed that peptides with non-proteinogenic structures should be attractive candidates as artificial bioactive peptides mimicking natural products, or so-called pseudo-natural products. We previously devised an engineered translation system for pseudo-natural peptides, referred to as the flexible in vitro translation (FIT) system. This system enabled “one-pot” synthesis of highly diverse pseudo-natural peptide libraries, which can be rapidly screened by mRNA display technology for the discovery of pseudo-natural peptides with diverse bioactivities.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 138 (1), 55-61, 2018-01-01

  The Pharmaceutical Society of Japan

Keywords

• <i>in vitro</i> biosynthesis
• pseudo-natural peptide
• macrocyclic peptide
• engineered translation

Details

• CRID: 1390282681192187392
• NII Article ID: 130006300866
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.17-00186-3
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 028774854
• PubMed: 29311466
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028774854
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/138/1/138_17-00186-3/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018302818
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed