New Gateways to the Platinum Group Metal-Catalyzed Direct Deuterium-Labeling Method Utilizing Hydrogen as a Catalyst Activator
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- Sawama Yoshinari
- Laboratory of Organic Chemistry, Gifu Pharmaceutical University
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- Park Kwihwan
- Laboratory of Organic Chemistry, Gifu Pharmaceutical University
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- Yamada Tsuyoshi
- Laboratory of Organic Chemistry, Gifu Pharmaceutical University
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- Sajiki Hironao
- Laboratory of Organic Chemistry, Gifu Pharmaceutical University
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Abstract
<p>Deuterium-labeled compounds are widely utilized in various scientific fields. We summarize the recent advances in the direct deuteration of sugar, saturated fatty acid, and arene derivatives using heterogeneous platinum group metal on carbon catalysts by our research group. Hydrogen gas is a key catalyst-activator to facilitate the present H–D exchange reactions. In this review, the direct activation method of catalysts using in situ-generated hydrogen based on the dehydrogenation of alcohols is introduced. The obtained multiple deuterium-labeled products, including bioactive compounds, are expected to contribute to the development of many scientific investigations.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 66 (1), 21-28, 2018
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679154642944
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- NII Article ID
- 130006301007
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 028738724
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- PubMed
- 29311508
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed