The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice

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  • Yoshikawa Ryouhei
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Yamamoto Hironori
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School Department of Health and Nutrition, Faculty of Human Life, Jin-ai University Department of Nephrology, Faculty of Medical Sciences, University of Fukui
  • Nakahashi Otoki
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School Division of Functional Food Chemistry, Institute for Health Science, Tokushima Bunri University
  • Kagawa Tomohiro
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Tajiri Mari
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Nakao Mari
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Fukuda Shiori
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Arai Hidekazu
    Laboratory of Clinical Nutrition and Management, Graduate School of Nutritional and Environmental Sciences, The University of Shizuoka
  • Masuda Masashi
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Iwano Masayuki
    Department of Nephrology, Faculty of Medical Sciences, University of Fukui
  • Takeda Eiji
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School
  • Taketani Yutaka
    Department of Clinical Nutrition and Food Management, Institute of Biomedical Sciences, University of Tokushima Graduate School

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Abstract

<p>In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.</p>

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