Acute Cerebellar Ataxia Associated with Anti-glutamic Acid Decarboxylase Antibodies Mimicking Miller Fisher Syndrome
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- Nakamura Yoshitsugu
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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- Nakajima Hideto
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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- Hosokawa Takafumi
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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- Yamane Kazushi
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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- Ishida Shimon
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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- Kimura Fumiharu
- Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan
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Abstract
<p>We herein report the case of a 53-year-old man with cerebellar ataxia with anti-glutamic acid decarboxylase antibody (GAD-Ab) who mimicked Miller Fisher syndrome (MFS). He developed ophthalmoplegia, diplopia, and gait ataxia for one week. The serum and cerebrospinal fluid GAD-Ab titers were greatly increased, and the GAD-Ab index suggesting intrathecal antibody synthesis was elevated, while GQ1b-Ab was negative. After steroid pulse therapy and following prednisolone, his symptoms dramatically improved over the course of 11 months with the simultaneous decline of GAD-Ab titers. This case indicates that cerebellar ataxia with GAD-Ab can present with acute neurological findings mimicking MFS, and that steroid therapy has an excellent therapeutic effect. </p>
Journal
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- Internal Medicine
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Internal Medicine 57 (2), 269-271, 2018
The Japanese Society of Internal Medicine
