Telomere-binding factors in the regulation of DNA replication

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Author(s)

Abstract

<p>Recent studies have indicated new roles for telomere-binding factors in the regulation of DNA replication, not only at the telomeres but also at the arm regions of the chromosome. Among these factors, Rif1, a conserved protein originally identified in yeasts as a telomere regulator, plays a major role in the spatiotemporal regulation of DNA replication during S phase. Its ability to interact with phosphatases and to create specific higher-order chromatin structures is central to the mechanism by which Rif1 exerts this function. In this review, we discuss recent progress in elucidating the roles of Rif1 and other telomere-binding factors in the regulation of chromosome events occurring at locations other than telomeres.</p>

Journal

  • Genes & Genetic Systems

    Genes & Genetic Systems 92(3), 119-125, 2017

    The Genetics Society of Japan

Codes

  • NII Article ID (NAID)
    130006316033
  • NII NACSIS-CAT ID (NCID)
    AA11077421
  • Text Lang
    ENG
  • ISSN
    1341-7568
  • NDL Article ID
    028761482
  • NDL Call No.
    Z53-W539
  • Data Source
    NDL  J-STAGE 
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