Galectin-9 Changes Its Function to Maintain Homeostasis

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  • Hirashima Mitsuomi
    Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University GalPharma Co., Ltd.
  • Niki Toshiro
    Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University GalPharma Co., Ltd.
  • Masaki Tsutomu
    Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University

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Other Title
  • Galectin-9は優しい生理活性物質：恒常性を保つために状態に応じて機能を変える

Abstract

<p>Galectin-9 (Gal-9)/Ecalectin was first identified as a T cell-derived eosinophil chemoattractant. We found that Gal-9 plays a role in not only the accumulation but also the activation of eosinophils in experimental allergic models and human allergic patients; Gal-9 was shown to induce eosinophil chemotaxis in vitro and in vivo and activated eosinophils in various aspects. Recent studies, however, showed that Gal-9 has other functions in the differentiation, maturation, aggregation, adhesion, and death of various cells. Presently, we and other groups are in the process of investigating the function of Gal-9 in a variety of physiological and pathological conditions. In this article, we will show the in vivo therapeutic effects of Gal-9 in various disease models (both hyper-immune and immune-compromised conditions), suggesting that Gal-9’s immune function changes according to the context. Indeed, the accumulated evidence suggests that Gal-9 orchestrates a variety of biological phenomena to maintain homeostasis.</p>

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