Mobilized Muse Cells After Acute Myocardial Infarction Predict Cardiac Function and Remodeling in the Chronic Phase
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- Tanaka Toshiki
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Nishigaki Kazuhiko
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Minatoguchi Shingo
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Nawa Takahide
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Yamada Yoshihisa
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Kanamori Hiromitsu
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Mikami Atsushi
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Ushikoshi Hiroaki
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Kawasaki Masanori
- Department of Cardiology, Gifu University Graduate School of Medicine
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- Dezawa Mari
- Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine
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- Minatoguchi Shinya
- Department of Cardiology, Gifu University Graduate School of Medicine
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Abstract
<p>Background:Multilineage differentiating stress-enduring (Muse) cells are SSEA3+and CD105+double-positive pluripotent-like stem cells. We aimed to examine the mobilization of Muse cells into peripheral blood after acute myocardial infarction (AMI) and their effects on left ventricular (LV) function and remodeling.</p><p>Methods and Results:In 79 patients with AMI, 44 patients with coronary artery disease (CAD), and 64 normal subjects (Control), we measured the number of Muse cells in the peripheral blood by fluorescence-activated cell sorting. Muse cells were measured on days 0, 1, 7, 14, and 21 after AMI. Plasma sphingosine-1-phosphate (S1P) levels were measured. Cardiac echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI. Muse cell number on day 1 was significantly higher in the AMI (276±137 cells/100 μL) than in the CAD (167±89 cells/100 μL) and Control (164±125 cells/100 μL) groups. Muse cell number peaked on day 1, and had gradually decreased on day 21. Muse cell number positively correlated with plasma S1P levels. Patients with a higher increase in the number of Muse cells in the peripheral blood but not those with a lower increase in number of Muse cells in the acute phase showed improved LV function and remodeling in the chronic phase.</p><p>Conclusions:Endogenous Muse cells were mobilized into the peripheral blood after AMI. The number of Muse cells could be a predictor of prognosis in patients with AMI.</p>
Journal
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- Circulation Journal
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Circulation Journal 82 (2), 561-571, 2018
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282680082911744
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- NII Article ID
- 130006321864
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 028782422
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- PubMed
- 28931784
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed