Entrance of Channel Determines Ion Permeation Rate through the Kv1.2 Channel

• SUMIKAMA Takashi

  Faculty of Medical Sciences, University of Fukui

• OIKI Shigetoshi

  Faculty of Medical Sciences, University of Fukui

Bibliographic Information

Other Title

• チャネルの入口がイオンの透過速度を決める
• チャネル ノ イリグチ ガ イオン ノ トウカ ソクド オ キメル

Abstract

Ion permeation through ion channels is essential for life. Since the determination of the x-ray crystal structure of the K⁺ channel, extensive molecular dynamics (MD) studies have been performed to visualize ion permeation through the channel. However, the mechanism underlying how the experimentally measured current amplitudes are determined still remains elusive. Here, we examined the MD-simulated trajectories of ion permeation through the Kv1.2 channel by developing a method analyzing the dynamics of ions. The analysis clarified that the entrance of ions into the channel determines the permeation rate.

Journal

• Seibutsu Butsuri

  Seibutsu Butsuri 58 (1), 012-016, 2018

  The Biophysical Society of Japan General Incorporated Association

Keywords

• ion channel
• ion permeation
• nanocavity
• molecular dynamics
• simulation
• Michaelis-Menten mechanism
• event-oriented analysis

Details

• CRID: 1390282681519475072
• NII Article ID: 130006322043
• NII Book ID: AN00129693
• DOI: 10.2142/biophys.58.012
• ISSN: 13474219
• ISSN: 05824052
• NDL BIB ID: 028871803
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028871803
• Web Site: https://www.jstage.jst.go.jp/article/biophys/58/1/58_012/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018126312
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed