Synthesis and Medicinal Chemistry of Muraymycins, Nucleoside Antibiotics

• Katsuyama Akira

  Faculty of Pharmaceutical Science, Hokkaido University

• Ichikawa Satoshi

  Faculty of Pharmaceutical Science, Hokkaido University Center for Research and Education on Drug Discovery, Hokkaido University

抄録

Muraymycins, isolated from a culture broth of Streptomyces sp., are members of a class of naturally occurring nucleoside antibiotics. They are strong inhibitors of the phospho-MurNAc-pentapeptide translocase (MraY), which is responsible for the peptidoglycan biosynthesis. Since MraY is an essential enzyme among bacteria, muraymycins are expected to be a novel antibacterial agent. In this review, our efforts to synthesize muraymycin D2, simplify the chemical structure, improve antibacterial spectrum, and solve the X-ray crystal structure of the muraymycin D2/MraY complex are described.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 66 (2), 123-131, 2018

  公益社団法人 日本薬学会

キーワード

• muraymycin
• nucleoside antibotics
• antibacterial agent
• total synthesis

詳細情報

• CRID: 1390001204178945280
• NII論文ID: 130006328055
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c17-00684
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 028787374
• PubMed: 29386462
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028787374
• Web Site: https://www.jstage.jst.go.jp/article/cpb/66/2/66_c17-00684/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019023837
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可