Improvement of Diet-induced Obesity by Ingestion of Mushroom Chitosan Prepared from Flammulina velutipes
-
- Miyazawa Noriko
- Faculty of Regional Environment Science, Tokyo University of Agriculture
-
- Yoshimoto Hiroaki
- Department of Civil and Environmental Engineering, Daiichi Institute of Technology
-
- Kurihara Shoichi
- Ricom Corporation
-
- Hamaya Tadao
- Ricom Corporation
-
- Eguchi Fumio
- Faculty of Regional Environment Science, Tokyo University of Agriculture
書誌事項
- タイトル別名
-
- Improvement of Diet-induced Obesity by Ingestion of Mushroom Chitosan Prepared from <i>Flamm</i><i>ulina velutipes</i>
この論文をさがす
抄録
<p>The anti-obesity effects of mushroom chitosan prepared from Flammulina velutipes were investigated using an animal model with diet-induced obesity. In this study, 5-week-old imprinting control region (ICR) mice were divided into six groups of 10 mice each and fed different diets based on the MF powdered diet (standard diet) for 6 weeks: standard diet control group, high-fat diet control group (induced dietary obesity) consisting of the standard diet and 20% lard, and mushroom chitosan groups consisting of the high-fat diet with mushroom chitosan added at 100, 500, 1,000, and 2,000 mg/kg body weight. On the final day of the experiment, mean body weight was 39.1 g in the high-fat control group and 36.3 g in the 2,000 mg/kg mushroom chitosan group, compared to 35.8 g in the standard diet control group. In the mushroom chitosan groups, a dose-dependent suppression of weight gain and marked improvements in serum triglycerides, total cholesterol, LDL-cholesterol, and HDL-cholesterol were found. The mushroom chitosan groups showed fewer and smaller fat deposits in liver cells than the high-fat diet control group, and liver weight was significantly reduced. Glutamic oxaloacetic transaminase (GOT) and glutamate pyruvic transaminase (GPT), which are indices of the hepatic function, all showed dose-dependent improvement with mushroom chitosan administration. These results suggested that mushroom chitosan acts to suppress enlargement of the liver from fat deposition resulting from a high-fat diet and to restore hepatic function. The lipid content of feces showed a marked increase correlated with the mushroom chitosan dose. These findings suggest the potential use of mushroom chitosan as a functional food ingredient that contributes to the prevention or improvement of dietary obesity by inhibiting digestion and absorption of fats in the digestive tract and simultaneously promotes lipolysis in adipocytes.</p>
収録刊行物
-
- Journal of Oleo Science
-
Journal of Oleo Science 67 (2), 245-254, 2018
公益社団法人 日本油化学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679068885120
-
- NII論文ID
- 130006328077
-
- NII書誌ID
- AA11503337
-
- ISSN
- 13473352
- 13458957
-
- NDL書誌ID
- 028784372
-
- PubMed
- 29367486
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可