Synthetic Studies on Heteropolycyclic Natural Products: Development of Divergent Strategy

• Shimokawa Jun

  Graduate School of Pharmaceutical Sciences, Nagoya University

Abstract

The divergent total syntheses of three types of heteropolycyclic natural products, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. A strategy involving a late-stage pluripotent common synthetic intermediate prepared via original and innovative transformations was employed. A brief description of the philosophy and criteria for choosing the synthetic targets and common synthetic precursors, as well as details regarding the development of the overall synthetic schemes from a common intermediate are discussed.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 66 (2), 105-115, 2018

  The Pharmaceutical Society of Japan

Keywords

• divergent synthesis
• natural product synthesis
• gelsedine-type alkaloid
• amathaspiramide alkaloid
• erythrina alkaloid

Details

• CRID: 1390001204178960000
• NII Article ID: 130006328172
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c17-00819
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 028787348
• PubMed: 29386459
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028787348
• Web Site: https://www.jstage.jst.go.jp/article/cpb/66/2/66_c17-00819/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed