The Role of Interleukin-19 in Contact Hypersensitivity

• Fujimoto Yasuyuki

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Fujita Takashi

  Laboratory of Molecular Toxicology, Department of Pharmaceutical Sciences, Ritsumeikan University

• Kuramoto Nobuyuki

  Laboratory of Molecular Pharmacology, Setsunan University Faculty of Pharmaceutical Sciences

• Kuwamura Mitsuru

  Laboratory of Veterinary Pathology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Izawa Takeshi

  Laboratory of Veterinary Pathology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Nishiyama Kazuhiro

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Yoshida Natsuho

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Nakajima Hidemitsu

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Takeuchi Tadayoshi

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

• Azuma Yasu-Taka

  Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science

Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2,4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)γ and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 41 (2), 182-189, 2018

  The Pharmaceutical Society of Japan

Keywords

• interleukin (IL)-19
• anti-inflammatory cytokine
• IL-17
• skin inflammation

Details

• CRID: 1390001204634370304
• NII Article ID: 130006329250
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.b17-00594
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 028787100
• PubMed: 29386478
• Web Site: http://id.ndl.go.jp/bib/028787100
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028787100
• Web Site: https://www.jstage.jst.go.jp/article/bpb/41/2/41_b17-00594/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019040820
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed