The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
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- Nakamura Yuya
- Department of Internal Medicine, Saiyu Soka Hospital, Japan Department of Pharmacology, School of Medicine, Showa University, Japan
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- Ohsawa Isao
- Department of Internal Medicine, Saiyu Soka Hospital, Japan
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- Goto Yoshikazu
- Department of Internal Medicine, Saiyu Soka Hospital, Japan
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- Namba Hokuto
- Department of Pharmacology, School of Medicine, Showa University, Japan
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- Dodo Yusuke
- Department of Pharmacology, School of Medicine, Showa University, Japan
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- Tsuji Mayumi
- Department of Pharmacology, School of Medicine, Showa University, Japan
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- Kiuchi Yuji
- Department of Pharmacology, School of Medicine, Showa University, Japan
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- Inagaki Masahiro
- Department of Chemistry, College of Arts and Sciences, Showa University, Japan
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- Gotoh Hiromichi
- Department of Internal Medicine, Saiyu Soka Hospital, Japan
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抄録
<p>A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection. After providing supportive treatment, the heart failure symptoms disappeared and her anemia had improved. This case emphasizes the need to include a B19V infection in the differential diagnosis when we encounter cases demonstrating reversible heart failure with anemia. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 57 (3), 403-407, 2018
一般社団法人 日本内科学会