Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/<i>RUNX1-RUNX1T1</i> Rearrangement

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Author(s)

    • Tokunaga Kenji
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Okuno Yutaka
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Yamamura Ayako
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Ueno Shikiko
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Kikukawa Yoshitaka
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Yamaguchi Shunichiro
    • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Japan
    • Hidaka Michihiro
    • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Japan
    • Matsuno Naofumi
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Kawaguchi Tatsuya
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan
    • Matsuoka Masao
    • Department of Hematology, Rheumatology, and Infectious Diseases, Faculty of Life Sciences, Kumamoto University, Japan

Abstract

<p>No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/<i>RUNX1-RUNX1T1</i> rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient. </p>

Journal

  • Internal Medicine

    Internal Medicine 57(4), 563-568, 2018

    The Japanese Society of Internal Medicine

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